In one study, a polysaccharide (glycogen) was extracted from Perna canaliculus and its anti-inflammatory activity was examined. The high molecular weight material was administered. I.V. and demonstrated a dose-dependent anti-inflammatory effect in rats with carrageenan-induced footpad edema. Mobilization of neutrophils to the site of the inflammatory stimulus was significantly reduced. This activity was lost if the glycogen extract was treated with KOH or proteinase K, suggesting that the inflammatory properties reside within a protein molecule associated with the glycogen.
There is no toxicity, cautions and contrain indications found.